• CAS No.：
  401916-61-8
• Synonyms：
  mPEG-Thiol
  SH-mPEG
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Methoxy PEG Thiol (mPEG-SH) is a linear monofunctional PEG, which has a free thiol group at one end that can selectively react with maleimide and transition metal surface including gold, silver, etc. mPEG SH is commonly used to modify gold or silver nanoparticles. Also, it can be easily oxidized by air through S-S disulfide bonds to form dimers, which can be reversed with reducing agents. 

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Hwira Baek, Eun-Cheol Lee, Marta Gonçalves, Yue Tong Ong, Saetbyeol Jeon, Young-Ju Jang, Sungbeen Kim, Yong Joo Seok, Seungpyo Hong, Suk Ho Bhang, Jin Woong Kim, Antioxidant biosurfactant-integrated stem cell nanovesicles for fibroblast reprogramming and membrane-protective wound healing, Chemical Engineering Journal, 2026, 182254, ISSN 1385-8947, https://doi.org/10.1016/j.cej.2026.182254
2. Kakizaki, M., Hikichi, M., Okawa, K., Maeki, M., Tokeshi, M., Suzuki, R., Gao, T., Li, F., Isono, T., Tajima, K., Satoh, T., Sato, S. I., & Yamamoto, T. (2026). Physisorption of Cyclic Poly(ethylene glycol) on Platinum Nanoparticles for Dispersion Stabilization and Catalytic Applications. Colloids and Interfaces, 10(3), 40. https://doi.org/10.3390/colloids10030040
3. Chaudhuri, T. R., Giesler, H., Sarmiento, M. K., Lamers, K., Hechler, M., Erkelenz, M., Haferkamp, M., Schirrmann, R., Nachev, M., Bosnjakovic, R., Sures, B., Schlücker, S., & Brandau, S. (2026). Systematic Evaluation of Physicochemical Properties of PEGylated Gold Nanorods Reveals Cell‐Specific Uptake Determinants in Human Immune Cell Subsets. Small Science, 6(3), e202500581. https://doi.org/10.1002/smsc.202500581
4. AFM-Based Single-Molecule Force Spectroscopy of PEG–Anti-PEG Antibody Interactions, Glenn Villena Latag, Hiroyuki Tahara, Airi Katase, Shoichi Maeda, Yiwei Liu, Yoshimitsu Kakuta, Takamasa Teramoto, Takeshi Mori, and Tomohiro Hayashi, ACS Applied Bio Materials Article ASAP, DOI: 10.1021/acsabm.5c01967
5. Porous silicon biosensors meet zwitterionic peptides: tackling biofouling from proteins to cells, Nanoscale Horiz., 2025, Advance Article, https://doi.org/10.1039/D5NH00478K
6. Chen, YC., Chang, LC., Liu, YL. et al. Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy. Nat Commun 16, 3253 (2025). https://doi.org/10.1038/s41467-025-58636-2 
7. In Vivo Ultrasound and Photoacoustic Imaging of Nanoparticle-Engineered T Cells and Post-Treatment Assessment to Guide Adoptive Cell Immunotherapy, Kelsey P. Kubelick, Jinhwan Kim, Myeongsoo Kim, Xinyue Huang, Chenxiao Wang, Seoyoon Song, Younan Xia, and Stanislav Y. Emelianov, ACS Nano 2025 19 (6), 6079-6094, DOI: 10.1021/acsnano.4c12929
8. Joung, H.; Jang, G.J.; Jeong, J.Y.; Lim, G.; Han, S.Y. Evaluating the In Situ Effects of Whole Protein Coronas on the Biosensing of Antibody-Immobilized Nanoparticles Using Two-Color Fluorescence Nanoparticle Tracking Analysis. Nanomaterials 2025, 15, 220. https://doi.org/10.3390/nano15030220 
9. Color-coded galectin fusion proteins as novel tools in biomaterial science,  Biomater. Sci., 2025,13, 1482-1500, https://doi.org/10.1039/D4BM01148A 
10.  Soon-Jae Lee et al. ,Spin angular momentum–encoded single-photon emitters in a chiral nanoparticle–coupled WSe2 monolayer.Sci. Adv.10,eadn7210(2024). DOI:10.1126/sciadv.adn7210 
11. Chan, C. K., Szeto, C. C., Lee, L. K., Xiao, Y., Yin, B., Ding, X., Lee, T. W., Lau, J. Y., & Choi, C. H. (2023). A sub-10-nm, folic acid-conjugated gold nanoparticle as self-therapeutic treatment of tubulointerstitial fibrosis. Proceedings of the National Academy of Sciences, 120(42), e2305662120. https://doi.org/10.1073/pnas.2305662120 
12. Jhunjhunwala A, Kim J, Kubelick KP, Ethier CR, Emelianov SY. In Vivo Photoacoustic Monitoring of Stem Cell Location and Apoptosis with Caspase-3-Responsive Nanosensors. ACS Nano. 2023;17(18):17931-17945. doi:10.1021/acsnano.3c04161 
13. Park S, Lim J, Kim S, et al. Anti-Inflammatory Artificial Extracellular Vesicles with Notable Inhibition of Particulate Matter-Induced Skin Inflammation and Barrier Function Impairment. ACS Appl Mater Interfaces. 2023;15(51):59199-59208. doi:10.1021/acsami.3c14377  
14. Retout, M., Jin, Z., Tsujimoto, J., Mantri, Y., Borum, R., Creyer, M. N., Yim, W., He, T., Chang, Y. C., & Jokerst, J. V. (2022). Di-Arginine Additives for Dissociation of Gold Nanoparticle Aggregates: A Matrix-Insensitive Approach with Applications in Protease Detection. ACS applied materials & interfaces, 14(46), 52553–52565. https://doi.org/10.1021/acsami.2c17531 
15. Colombo M, Marongiu L, Mingozzi F, et al. Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells. iScience. 2022;25(10):105042. Published 2022 Aug 30. doi:10.1016/j.isci.2022.105042 
16. Lee, M. S., Park, Y., Kim, S. R., Jung, Y. M., & Yoo, H. S. (2022). Dual irradiation-triggered anticancer therapeutics composed of polydopamine-coated gold nanoparticles. Biomaterials Advances, 136, 212779. https://doi.org/10.1016/j.bioadv.2022.212779 
17. Blood-brain Barrier Crossing using Magnetic Stimulated Nanoparticles, Jingfan Chen, Muzhaozi Yuan, Caitlin A Madison, Shoshana Eitan, Ya Wang, bioRxiv 2021.12.23.472846; doi: https://doi.org/10.1101/2021.12.23.472846 
18. Jang, W., Kim, J., Mun, S. J., Kim, S. M., & Bong, K. W. (2021). Highly Magnetized Encoded Hydrogel Microparticles with Enhanced Rinsing Capabilities for Efficient microRNA Detection. Biomedicines, 9(7), 848. https://doi.org/10.3390/biomedicines9070848 
19. Aido, A., Zaitseva, O., Wajant, H., Buzgo, M., & Simaite, A. (2021). Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism. Pharmaceutics, 13(7), 1072. https://doi.org/10.3390/pharmaceutics13071072 
20. Alfonso, M., Aznar, E., Orzáez, M., Marcos, M. D., & Sancenón, F. (2021). Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells. Nanomaterials, 11(5), 1298. https://doi.org/10.3390/nano11051298

View more publications citing Biopharma PEG products.

Related Products & Categories

• ● Category: Monofunctional mPEG Derivatives |  Polydispersed Thiol PEGs
• ● Amine-Reactive mPEGs: mPEG-NHS |  mPEG-SPA  | mPEG-SS |  mPEG-pALD | mPEG-bALD
• ● Surface & Functional mPEGs: mPEG-Silane | mPEG-Br
• ● Amine & Azide mPEGs: mPEG-NH2 | mPEG-Azide
• ● Hydroxyl Precursor: mPEG-OH