• Synonyms：
  NH2HCl-PEG-COOH
  Amine-PEG-Acid
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

NH2-PEG-COOH (Amine-PEG-Acid) is a linear heterobifunctional PEG derivative featuring a terminal primary amine (-NH2) group at one end and a carboxylic acid (-COOH) group at the other. The dual orthogonal functional end-groups separated by a hydrophilic poly(ethylene glycol) spacer make it an essential reagent for protein & peptide PEGylation, bioconjugation, surface modification, and advanced drug delivery systems.

Cited Publications

The NH2-PEG-COOH has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Schmidt, J., Ziegler, L., Kaps, F. T., Rosenberger, L. J., Bros, M., Frey, H., & Luxenhofer, R. A Non-Antigenic Randomized Polyethylene Glycol/Poly(2-Phenyl-2-Oxazine)-Based Drug Delivery Platform. Macromolecular Rapid Communications, e00781. https://doi.org/10.1002/marc.202500781
2. Matsudaira, N., Honda, Y., Kinoh, H., Liu, X., Nagao, S., Matsutomo-Nitta, S., Haochen, G., Hayashita-Kinoh, H., Aizawa, M., Muguruma, K., Miura, Y., Shishido, A., Okada, T., & Nishiyama, N. (2025). Tumor-targeted adeno associated virus-loaded complexes comprising tannic acid and phenylboronic acid-polymers for orthotopic glioblastoma therapy. Journal of Controlled Release, 114477. https://doi.org/10.1016/j.jconrel.2025.114477
3. Han, B. H., Park, M., Chung, S., & Kang, J. Y. (2026). Evaporation-driven digital ELISA with micro-droplet arrays for ultrafast detection of low-abundance proteins. Biosensors and Bioelectronics, 292, 118076. https://doi.org/10.1016/j.bios.2025.118076
4. Melanie Carroll, Heather B. Fox, Anh Tran, Gowri Chellappan, Leonardo V. Rojas, Geetha Karengil, Fataneh Karandish, John W. Langston, Brent M. Fall, Mary M. Whalen, Michael J. McCluskie, Yves Durocher, Anup Datta, Subhash V. Kapre, Ivan A. Olave, SARS-CoV-2 conjugate vaccine elicits robust immune responses that can protect against evolving variants., Vaccine, Volume 54, 2025, 126988, ISSN 0264-410X, https://doi.org/10.1016/j.vaccine.2025.126988. 
5. Min-Hua Lai, Wen Jen Lin, Zein-PEG nanoparticles modified with hyaluronic acid for paclitaxel delivery in SKOV3 ovarian cancer cells, International Journal of Biological Macromolecules, Volume 281, Part 4, 2024, 136651, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.136651. 
6. Chen, Y., Chen, F. Co-crosslinking strategy for dual functionalization of small magnetic nanoparticles with redox probes and biological probes. Microchim Acta 191, 448 (2024). https://doi.org/10.1007/s00604-024-06517-8 
7. Synthesis and aptamer-targeted nanoparticle delivery of ruthenium(III) theranostics,  Farzaneh, Saeid, https://summit.sfu.ca/item/38147 
8. Ko S, Kim JY, Park JY, et al. Modulating the folding and binding of peptides using a stimuli-responsive molecular tweezer. Chem Sci. 2023;14(35):9600-9607. Published 2023 Sep 1. doi:10.1039/d3sc03758d 
9. Shitole, A. A., Sharma, N., Giram, P., Khandwekar, A., Baruah, M., Garnaik, B., & Koratkar, S. (2020). LHRH-conjugated, PEGylated, poly-lactide-co-glycolide nanocapsules for targeted delivery of combinational chemotherapeutic drugs Docetaxel and Quercetin for prostate cancer. Materials Science and Engineering: C, 114, 111035. https://doi.org/10.1016/j.msec.2020.111035

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