• CAS No.：
  474922-22-0
• Synonyms：
  DSPE-PEG-Maleimide
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

DSPE-PEG-Maleimide (DSPE-PEG-MAL) is one of phospholipid PEG derivatives that composed of DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine)  and maleimide groups. DSPE-PEG-MAL is one of the most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have extended blood circulation time and higher stability for encapsulated drugs.

It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the reactive maleimide to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

Biopharma PEG provides high purity DSPE-PEG-MAL with various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery. Email at sales@biochempeg.com for more information. 


References：
1. Afatinib-loaded Immunoliposomes Functionalized with Cetuximab: a Novel Strategy Targeting the Epidermal Growth Factor Receptor for Treatment of Non-small-cell Lung Cancer------ International Journal of Pharmaceutics（IF=3.862）
2. Layer-by-Layer Heparinization of the Cell Surface by Using Heparin-Binding Peptide Functionalized Human Serum Albumin------ Materials(IF=2.467)
3. Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging------ Nature Nanotechnology(IF=37.49)
4. Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway------Acs applied  materials&interfaces（IF=8.097）
5. Biomimetic virus-like and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery Acs applied  materials&interfaces（IF=8.097）
6. Enhanced legumain-recognition and NIR controlled released of cisplatin-indocyanine nanosphere against gastric carcinoma------ European Journal of Pharmacology（IF=3.04）