• CAS No.：
  147867-65-0
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

mPEG-DSPE is a linear PEG lipid with saturated C18 stearoyl fatty acid (octadecanoic acid), which contains hydrophilic and hydrophobic phospholipid PEG conjugates. The PEG phospholipids contained in mPEG-DSPE can be used in the formation of stealth liposomes or micelles and can be used in targeted drug delivery and drug solubility enhancement.

The PEGylation of PEG phospholipids can also improve the blood circulation time and stability of encapsulated drugs and can be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies and peptides.

Cited Publications

Our mPEG-DSPE has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Modular Albumin-Chaperoned NIR-II Nanofluorophores Enables Pan-Ovarian Cancer Imaging Across Multiscale Tumor Models, Isabella Vasquez, Lucia L. Nash, Md Shahriar, Mahenour Megahed, Jerry Cao-Xue, Itzel De León, Changxue Xu, Ulrich Bickel, Shreya A. Raghavan, Indrajit Srivastava, bioRxiv 2026.05.06.717945; doi: https://doi.org/10.64898/2026.05.06.717945
2. ​PEGylated lipid screening, composition optimization, and structure–activity relationship determination for lipid nanoparticle-mediated mRNA deliver, https://doi.org/10.1039/D5NR00433K 
3. Junsheng Chen, Karina Juhl, Fuxue Zhang, Yanmei He, Amar H. Flood, Andreas Kjaer, Bo W. Laursen; Bright Near-Infrared-Emitting Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices. ACS Appl. Nano Mater. 17 October 2025; 8 (41): 19739–19747. https://doi.org/10.1021/acsanm.5c02607
4. Chuan-chung Chuang, Cheng-cheung Chen, Xin-an Chen, Chia-ying Lee, Yu-hsiu Chang, Meng-hung Tsai, Jenn-jong Young, Chuan-chang Chuang,Enhancing the in vivo efficacy of anthrax vaccine using trimethylchitosan covalently coated chitosomes in a single-step microfluidic synthesis, International Journal of Biological Macromolecules, Volume 304, Part 1, 2025, 140689, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2025.140689. 
5. van den Broek, M.R.P., Versluis, M., van den Berg, A. et al. Functionalized monodisperse microbubble production: microfluidic method for fast, controlled, and automated removal of excess coating material. Microsyst Nanoeng 10, 120 (2024). https://doi.org/10.1038/s41378-024-00760-y 
6. Stenspil, S. G., Chen, J., Liisberg, M. B., Flood, A. H., & Laursen, B. W. (2024). Control of the fluorescence lifetime in dye based nanoparticles. Chemical science, 15(15), 5531–5538. https://doi.org/10.1039/d3sc05496a 
7. M. Sela, M. Poley, P. Mora-Raimundo, S. Kagan, el., Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease. Adv. Mater. 2023, 35, 2304654. https://doi.org/10.1002/adma.202304654 
8. Quantitative Energy Transfer in Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices for UV Light Harvesting, Junsheng Chen, Stine G. Stenspil, Spyridon Kaziannis, Laura Kacenauskaite, Nils Lenngren, Miroslav Kloz, Amar H. Flood, and Bo W. Laursen, ACS Applied Nano Materials 2022 5 (10), 13887-13893, DOI: 10.1021/acsanm.2c01899 
9. Arber Raviv, S., Alyan, M., Egorov, E., Zano, A., Harush, M. Y., Pieters, C., Korach-Rechtman, H., Saadya, A., Kaneti, G., Nudelman, I., Farkash, S., Flikshtain, O. D., Mekies, L. N., Koren, L., Gal, Y., Dor, E., Shainsky, J., Shklover, J., Adir, Y., . . . Schroeder, A. (2022). Lung targeted liposomes for treating ARDS. Journal of Controlled Release, 346, 421-433. https://doi.org/10.1016/j.jconrel.2022.03.028

View more publications citing Biopharma PEG products.

Related Technical Articles & Guides

• ● PEG Lipids: Definition, Structure & Key Applications 
• ● The Role of Four Lipid Components Of LNPs
• ● Ultimate Insight into PEG Derivatives and Its Application

Related Products & Categories

• ● Category: Lipids for Lipid Nanoparticles (LNPs) | DSPE PEG
• ● Phospholipid Building Block: DSPE , DPPE
• ● PEG Lipids:  mPEG-DMG 
• ● Functionalized PEG Lipids: DSPE-PEG-MAL , DSPE-PEG-NH2, DSPE-PEG-NHS
• ● Targeting PEG Lipids:  DSPE-PEG-Mannose, DSPE-PEG-c(RGDyk) 
• ● Other LNP Lipids: Cholesterol (Plant-Derived)