CatalogID: 10449 Purity: ≥95% CAS NO.: 147867-65-0

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    Store at -5°C,keep in dry and avoid sunlight.
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mPEG-DSPE is a linear PEG phospholipid with saturated C18 stearoyl fatty acid (octadecanoic acid), which contains hydrophilic and hydrophobic phospholipid PEG conjugates. The PEG phospholipids contained in mPEG-DSPE can be used in the formation of stealth liposomes or micelles and can be used in targeted drug delivery and drug solubility enhancement.

The PEGylation of PEG phospholipids can also improve the blood circulation time and stability of encapsulated drugs and can be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies and peptides.

The BioNTech/Pfizer and Moderna COVID-19 mRNA vaccines exploit LNP drug delivery system, the mPEG-DSPE has become a very useful material for the formulation of these vaccines. 

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Besides PEG lipids, we can also provide helper lipids, such as cholesterol (plant-derived), and DSPE for your LNP formulation development.Email at and start using a superior product for your next product R&D project.

1. ​Che J, Okeke CI, Hu ZB, Xu J. DSPE-PEG: a distinctive component in drug delivery system. Curr Pharm Des. 2015;21(12):1598-605. doi: 10.2174/1381612821666150115144003. PMID: 25594410.
2. Schoenmaker, Linde; Witzigmann, Dominik; Kulkarni, Jayesh A.; Verbeke, Rein; Kersten, Gideon; Jiskoot, Wim; Crommelin, Daan J. A. (2021-05-15). "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability". International Journal of Pharmaceutics. 601: 120586. doi:10.1016/j.ijpharm.2021.120586. ISSN 0378-5173.

mPEG-DSPE MSDS download