• CAS No.：
  147867-65-0
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

mPEG-DSPE is a linear PEG phospholipid with saturated C18 stearoyl fatty acid (octadecanoic acid), which contains hydrophilic and hydrophobic phospholipid PEG conjugates. The PEG phospholipids contained in mPEG-DSPE can be used in the formation of stealth liposomes or micelles and can be used in targeted drug delivery and drug solubility enhancement.

The PEGylation of PEG phospholipids can also improve the blood circulation time and stability of encapsulated drugs and can be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies and peptides.

The BioNTech/Pfizer and Moderna COVID-19 mRNA vaccines exploit LNP drug delivery system, the mPEG-DSPE has become a very useful material for the formulation of these vaccines. 

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Besides PEG lipids, we can also provide helper lipids, such as cholesterol (plant-derived), and DSPE for your LNP formulation development.Email at sales@biochempeg.com and start using a superior product for your next product R&D project.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. ​PEGylated lipid screening, composition optimization, and structure–activity relationship determination for lipid nanoparticle-mediated mRNA deliver, https://doi.org/10.1039/D5NR00433K 
2. Chuan-chung Chuang, Cheng-cheung Chen, Xin-an Chen, Chia-ying Lee, Yu-hsiu Chang, Meng-hung Tsai, Jenn-jong Young, Chuan-chang Chuang,
   Enhancing the in vivo efficacy of anthrax vaccine using trimethylchitosan covalently coated chitosomes in a single-step microfluidic synthesis, International Journal of Biological Macromolecules, Volume 304, Part 1, 2025, 140689, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2025.140689. 
3. van den Broek, M.R.P., Versluis, M., van den Berg, A. et al. Functionalized monodisperse microbubble production: microfluidic method for fast, controlled, and automated removal of excess coating material. Microsyst Nanoeng 10, 120 (2024). https://doi.org/10.1038/s41378-024-00760-y 
4. Stenspil, S. G., Chen, J., Liisberg, M. B., Flood, A. H., & Laursen, B. W. (2024). Control of the fluorescence lifetime in dye based nanoparticles. Chemical science, 15(15), 5531–5538. https://doi.org/10.1039/d3sc05496a 
5. M. Sela, M. Poley, P. Mora-Raimundo, S. Kagan, el., Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease. Adv. Mater. 2023, 35, 2304654. https://doi.org/10.1002/adma.202304654 
6. Quantitative Energy Transfer in Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices for UV Light Harvesting, Junsheng Chen, Stine G. Stenspil, Spyridon Kaziannis, Laura Kacenauskaite, Nils Lenngren, Miroslav Kloz, Amar H. Flood, and Bo W. Laursen, ACS Applied Nano Materials 2022 5 (10), 13887-13893, DOI: 10.1021/acsanm.2c01899 
7. Arber Raviv, S., Alyan, M., Egorov, E., Zano, A., Harush, M. Y., Pieters, C., Korach-Rechtman, H., Saadya, A., Kaneti, G., Nudelman, I., Farkash, S., Flikshtain, O. D., Mekies, L. N., Koren, L., Gal, Y., Dor, E., Shainsky, J., Shklover, J., Adir, Y., . . . Schroeder, A. (2022). Lung targeted liposomes for treating ARDS. Journal of Controlled Release, 346, 421-433. https://doi.org/10.1016/j.jconrel.2022.03.028

View more publications citing Biopharma PEG products.