• Synonyms：
  DSPE-PEG-NHS
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

DSPE-PEG-SC, also known as DSPE-PEG-NHS, is a widely used DSPE-PEG derivative designed for lipid-based drug delivery and surface functionalization. It features a hydrophobic DSPE moiety, a hydrophilic PEG spacer, and a terminal succinimidyl ester (SC/NHS) group, forming a well-structured amphiphilic molecule with both stability and reactivity.

As a reactive DSPE-PEG conjugate, the NHS ester group can efficiently react with primary amines under mild conditions, enabling covalent attachment of biomolecules such as antibodies, peptides, proteins, and aptamers. This makes DSPE-PEG-SC particularly suitable for  used in liposome surface modification, targeted drug delivery, and biomaterial engineering, providing both structural support and chemical versatility for advanced nanomedicine systems.

Cited Publications

The DSPE-PEG-SC has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Shen, Y., Lante Lamptey, R. N., Mareddy, G. R., Chaulagain, B., Singh, J., & Sun, C. (2025). Engineered Liposomal Delivery of Human ACE2 Across the Blood–Brain Barrier Attenuated Neurogenic Hypertension. Pharmaceutics, 17(10), 1329. https://doi.org/10.3390/pharmaceutics17101329
2. Richard Nii Lante Lamptey, Chengwen Sun, Jagdish Singh, Intranasal administration of angiotensin receptor shRNA to brain lowers blood pressure in spontaneously hypertensive rats, Biomedicine & Pharmacotherapy, Volume 182, 2025, 117790, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2024.117790.
3. Lubitz, L.J.; Haffner, M.P.; Rieger, H.; Leneweit, G. Elevated Cellular Uptake of Succinimide- and Glucose-Modified Liposomes for Blood–Brain Barrier Transfer and Glioblastoma Therapy. Biomedicines 2024, 12, 2135. https://doi.org/10.3390/biomedicines12092135 
4. Blood pressure reduction through brain delivery of nanoparticles loaded with plasmid DNA encoding angiotensin receptor shRNA, Lamptey, Richard Nii Lante et al., Molecular Therapy Nucleic Acids, Volume 35, Issue 2, 102210, https://doi.org/10.1016/j.omtn.2024.102210 
5. Chaeeun Bang, Min Gyu Park, In Kyung Cho, Da-Eun Lee, Gye Lim Kim, Eun Hyang Jang, Man Kyu Shim, Hong Yeol Yoon, Sangmin Lee, Jong-Ho Kim. Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy. Biomater Res. 2023;27:53.DOI:10.1186/s40824-023-00394-7 
6. Lamptey RNL, Sun C, Singh J. Brain-targeted delivery of losartan through functionalized liposomal nanoparticles for management of neurogenic hypertension. Int J Pharm. 2023;637:122841. doi:10.1016/j.ijpharm.2023.122841 
7. Arora, S., Kanekiyo, T., & Singh, J. (2022). Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model. International Journal of Biological Macromolecules, 208, 901-911. https://doi.org/10.1016/j.ijbiomac.2022.03.203 
8. Rodrigues, S., Lakkadwala, S., Kanekiyo, T., & Singh, J. (2020). Dual-Modified Liposome for Targeted and Enhanced Gene Delivery into Mice Brain. The Journal of Pharmacology and Experimental Therapeutics, 374(3), 354. https://doi.org/10.1124/jpet.119.264127 
9. Rodrigues, S., Lakkadwala, S., Kanekiyo, T., & Singh, J. (2019). Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. International Journal of Nanomedicine, 14, 6497. https://doi.org/10.2147/IJN.S215941 
10. Lakkadwala, S., Dos Santos Rodrigues, B., Sun, C., & Singh, J. (2019). Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma. Journal of Controlled Release, 307, 247-260. https://doi.org/10.1016/j.jconrel.2019.06.033 
11. Dos Santos Rodrigues, B., Banerjee, A., Kanekiyo, T., & Singh, J. (2019). Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection. International Journal of Pharmaceutics, 566, 717-730. https://doi.org/10.1016/j.ijpharm.2019.06.026 
12. Lakkadwala, S., & Singh, J. (2018). Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model. Colloids and Surfaces B: Biointerfaces, 173, 27-35. https://doi.org/10.1016/j.colsurfb.2018.09.047

View more publications citing Biopharma PEG products.

Related Technical Articles & Guides

• ● PEG Lipids: Definition, Structure & Key Applications 
• ● The Role of Four Lipid Components Of LNPs
• ● Ultimate Insight into PEG Derivatives and Its Application

Related Products & Categories

• ● Category: Lipids for Lipid Nanoparticles (LNPs)
• ● Phospholipid Building Block: DSPE
• ● PEG Lipids:  mPEG-DSPE, mPEG-DMG 
• ● Functionalized PEG Lipids: DSPE-PEG-MAL , DSPE-PEG-NH2
• ● Targeting PEG Lipids:  DSPE-PEG-Mannose, DSPE-PEG-c(RGDyk) 
• ● Other LNP Lipids: Cholesterol (Plant-Derived)