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Monodispersed PEGs
- >Methoxy PEG (mPEG)
- >Azide(N3) PEG
- >Amine(NH2) PEG
- >Hydroxyl(OH) PEG
- >Thiol(SH) PEG
- >Boc/Fmoc PEG
- >Carboxylic Acid(COOH) PEG
- >Maleimide(Mal) PEG
- >Alkyne PEG
- >NHS ester PEG
- >Biotin PEG
- >Aldehyde (Ald/CHO)PEG
- >Acrylate(AC) PEG
- >Acrylamide(ACA) PEG
- >DBCO PEG
- >DSPE PEG
- >Other Lipid PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Methacrylate (MA) PEG
- >Silane PEG
- >PEG Sulfonic acid
- >PEG PFP ester
- >PEG TFP ester
- >Halide (F,Cl,Br,I) PEG
- >Benzyl-PEG
- >Aminooxy PEG
- >Fluorescent (FITC) PEG
- >Rhodamine B(RB) PEG
- >Cholesterol PEG
- >OPSS PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >DNP PEG
- >Other PEG
- >PROTAC Linker
- >Hydrocarbons PEG
- >View More
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Polydispersed PEGs
- >Methoxy PEG (mPEG)
- >Azide(N3) PEG
- >Amine(NH2) PEG
- >Hydroxyl(OH) PEG
- >Thiol(SH) PEG
- >DSPE PEG
- >Carboxylic Acid(COOH) PEG
- >Maleimide(Mal) PEG
- >NHS ester PEG
- >Acrylate(AC) PEG
- >Boc/Fmoc PEG
- >Biotin PEG
- >Aldehyde (Ald/CHO)PEG
- >Fluorescent (FITC) PEG
- >Cyanine (Cy) PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Silane PEG
- >Cholesterol PEG
- >DBCO PEG
- >Alkyne PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >OPSS PEG
- >Acrylamide(ACA) PEG
- >PLGA PEG
- >PCL PEG
- >PLA PEG
- >PEG Sulfonic acid
- >PEG PFP ester
- >Halide (F,Cl,Br,I) PEG
- >Aminooxy PEG
- >Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Methacrylate (MA) PEG
- >Rhodamine B(RB) PEG
- >Other Lipid PEG
- >Other PEG
- >Hydrocarbons PEG
- >View More
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Multi-arm PEGs
- >Hydroxyl(OH) PEG
- >NHS ester PEG
- >Amine(NH2) PEG
- >Maleimide(Mal) PEG
- >Azide(N3) PEG
- >Thiol(SH) PEG
- >DBCO PEG
- >Carboxylic Acid(COOH) PEG
- >Aldehyde (Ald/CHO)PEG
- >Methoxy PEG (mPEG)
- >Acrylate(AC) PEG
- >Biotin PEG
- >Cholesterol PEG
- >OPSS PEG
- >Acrylamide(ACA) PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Methacrylate (MA) PEG
- >Silane PEG
- >Halide (F,Cl,Br,I) PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >Other PEG
- >View More
- >Hydrocarbons PEG
- PEGs by Application
- Lipid Nanoparticle (LNP) Lipids
- Nucleic Acid Chemistry
- PEG Raw Material
- On Sale PEG Linkers
- Recombinant Proteins
CatalogID: 10456 Purity: ≥95% CAS NO.: 1403744-37-5
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CAS No.：
1403744-37-5 -
Synonyms：
DSPE-PEG-Acid
DSPE-PEG-Carboxylic acid
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Purity：
≥95% -
Recommended Storage Condition：
Store at -5°C,keep in dry and avoid sunlight. -
Uses：
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
Carboxyl-Functionalized PEG Lipid for Liposomes, Lipid Nanoparticles, and Bioconjugation
DSPE-PEG-COOH (DSPE-PEG-Acid) is a carboxyl-terminated PEG lipid with a hydrophobic C18 DSPE tail, a hydrophilic stealth PEG chain, and a terminal reactive carboxylic acid group (-COOH).
DSPE-PEG-COOH serves as an essential building block for targeted liposomes, lipid nanoparticles (LNPs), and polymeric nanocarriers. The terminal carboxylic acid can be activated for coupling with primary amines, making the reagent useful for attaching peptides, proteins, antibodies, aptamers, and other amine-containing ligands.
Cited Publications
This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.
- Hee Won Park, Dae Hyun Lee, Sungjun Kim, Hyeri Park, Ashok Kumar Jangid, Chae Eun Lee, Jaewon Park, Gyu Tae Park, Ha Yeon Park, HyunJin Kim, Jae Ho Kim, Gi Jin Kim, Kyobum Kim, Amphiphilic Lipid-Peptide Engineered Placenta-Derived Mesenchymal Stem Cells for Liver Fibrosis Treatment, Asian Journal of Pharmaceutical Sciences, 2025, 101061, ISSN 1818-0876, https://doi.org/10.1016/j.ajps.2025.101061.
- Bone Marrow-Targeted Liposomes Loaded with Bortezomib Overcome Multiple Myeloma Resistance, Rotem Menachem, Igor Nudelman, Avital Vorontsova, Ido Livneh, Mor Sela, Madeleine Benguigui, Bar Manobla, Yael Shammai, Abhilash Deo, Chen Buxbaum, Ron Bessler, Ziv Raviv, Jeny Shklover, Josué Sznitman, Aaron Ciechanover, Avi Schroeder, and Yuval Shaked, ACS Nano 2025 19 (12), 11684-11701, DOI: 10.1021/acsnano.4c10597
- Luo, C., Hsu, Y., Wu, W., Chang, K., & Yeh, C. (2021). Phage Digestion of a Bacterial Capsule Imparts Resistance to Two Antibiotic Agents. Microorganisms, 9(4), 794. https://doi.org/10.3390/microorganisms9040794
View more publications citing Biopharma PEG products.
Related Technical Articles & Guides
- ● PEG Lipids: Definition, Structure & Key Applications
- ● The Role of Four Lipid Components Of LNPs
- ● Ultimate Insight into PEG Derivatives and Its Application
Related Products & Categories
- ● Category: Lipids for Lipid Nanoparticles (LNPs) | DSPE PEG
- ● Phospholipid Building Block: DSPE , DPPE
- ● PEG Lipids: mPEG-DSPE, mPEG-DMG
- ● Functionalized PEG Lipids: DSPE-PEG-NH2, DSPE-PEG-MAL , DSPE-PEG-NHS
- ● Targeting PEG Lipids: DSPE-PEG-Mannose, DSPE-PEG-c(RGDyk)
- ● Other LNP Lipids: Cholesterol (Plant-Derived)
Need Custom DSPE-PEG Conjugates or Specific Molecular Weights?
Biopharma PEG provides high-purity DSPE-PEG-COOH across a wide range of PEG molecular weights in both research scale and commercial GMP grade quantities. We also offer custom synthesis for specialized lipid anchors, precise linkers, and targeted ligand attachments tailored to your LNP and liposome drug delivery project.
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